Advancing our understanding of Alzheimer’s Disease and accelerating a cure.

What We Do

Our main research interest is to understand the molecular, cellular and circuit underpinnings of memory loss and cognitive decline in Alzheimer’s disease. We seek to understand how the proteins that accumulate in the Alzheimer brain, tau and amyloid, impair the function of individual neurons and large-scale circuits and how these alterations are related to disease progression. For that purpose, we are studying models of Alzheimer’s disease using a variety of in vitro and in vivo approaches including one and multiphoton microscopy, electrophysiology, optogenetics and wide-field network imaging in combination with molecular and cell biological techniques. In doing so, we hope to contribute to solving the complicated problem of Alzheimer’s disease and accelerate a cure for this devastating disease.

Who We Are

Marc Aurel Busche, M.D., Ph.D.
Marc Aurel Busche, M.D., Ph.D.
Principal Investigator

• POSITION
Programme Lead, UK Dementia Research Institute
Honorary Consultant, National Hospital for Neurology and Neurosurgery

• EDUCATION
Massachusetts General Hospital & Harvard Medical School
EMBO Long-Term Fellow, Hyman Laboratory
Technical University of Munich
Clinical Residency in Psychiatry
Postdoc, Konnerth Laboratory
PhD, Medical Life Sciences and Technology

• AWARDS
AD/PD Junior Faculty Award, Kurt Kaufmann Prize, GSK Award for Clinical Research, EMPIRIS Award, Felgenhauer Award, Hans Jörg Weitbrecht Prize, Hans Heimann Prize

PUBMED



Samuel Harris, Ph.D.
Samuel Harris, Ph.D.

• POSITION
Research Laboratory Manager

• EDUCATION & PREVIOUS POSITIONS
Springer Nature, London
Scientific Editor
University of Sheffield & Weill Cornell Medical College New York
Postdoctoral Fellow
University of Sheffield
Ph.D

 

Jana Hartmann, Ph.D.
Jana Hartmann, Ph.D.

• POSITION
Research Fellow

• EDUCATION & PREVIOUS POSITIONS
Technical University of Munich
Research Associate, Konnerth Laboratory
Saarland University
Postdoctoral Fellow
Max Delbrueck Centrum for Molecular Medicine, Berlin
Postdoctoral Fellow
Max Planck Institute for Medical Research, Heidelberg
PhD

 

Byung Il Lee, Ph.D.
Byung Il Lee, Ph.D.

• POSITION
Research Fellow

• EDUCATION & PREVIOUS POSITIONS
Korea Advanced Institute for Science and Technology (KAIST)
PhD

 

 

 

Seminars

Dr. Neil Oxtoby
UCL Department of Computer Science

An introduction to data-driven computational modelling of neurodegenerative disease progression

Thursday 31 October 2019
12PM – 1PM
Cruciform Building, Gower Street, Foyer Meeting Room 2

 

 

Dr. Ulf Neumann
Novartis Institutes of BioMedical Research, Basel, Switzerland

BACE inhibitor CNP520 for prevention of Alzheimer’s disease

Wednesday 18 September 2019
3PM – 4.30PM
Cruciform Building, Gower Street, Boardroom


 

Dr. Hongbo Jia
Suzhou Institute of Biomedical Engineering and Technology,
Chinese Academy of Sciences


‘Holistic Bursting’: A logic of learning-transformed single-cell firing mode

Friday 13 September 2019
12PM – 13PM
Cruciform Building, Gower Street, Boardroom

Join us

 

We are looking for exceptional scientists to build a multidisciplinary team of researchers passionate about neuroscience! Candidates with experience in in vivo electrophysiology and/or imaging are especially encouraged to apply. If you are looking for a position as a PhD student or Postdoc please send us an email. Please include a brief description of your experiences, interests, and current and future goals. Coming with fellowship funding is always a big plus.