Advancing our understanding of Alzheimer’s Disease and accelerating a cure.

What We Do

Our main research interest is to understand the cellular and circuit underpinnings of memory loss and cognitive decline in Alzheimer’s disease. We seek to understand how the proteins that accumulate in the Alzheimer brain, tau and amyloid, impair the function of individual neurons and large-scale circuits and how these alterations are related to disease progression. For that purpose, we are studying models of Alzheimer’s disease using a variety of in vivo approaches including multiphoton microscopy, electrophysiology and wide-field network imaging in combination with molecular and cell biological techniques. In doing so, we hope to contribute to solving the complicated problem of Alzheimer’s disease and accelerate a cure for this devastating disease.

Who We Are

Marc Aurel Busche, M.D., Ph.D.
Principal Investigator

Programme Lead, UK Dementia Research Institute
Honorary Consultant, National Hospital for Neurology and Neurosurgery

Massachusetts General Hospital & Harvard Medical School
EMBO Long-Term Fellow, Hyman Laboratory
Technical University of Munich
Clinical Residency in Psychiatry
Postdoc, Konnerth Laboratory
PhD, Medical Life Sciences and Technology

AD/PD Junior Faculty Award, Kurt Kaufmann Prize, GSK Award for Clinical Research, EMPIRIS Award, Felgenhauer Award, Hans Jörg Weitbrecht Prize, Hans Heimann Prize


Samuel Harris, Ph.D.

Research Laboratory Manager

Springer Nature, London
Scientific Editor
University of Sheffield & Weill Cornell Medical College New York
Postdoctoral Fellow
University of Sheffield


Jana Hartmann, Ph.D.

Research Fellow

Technical University of Munich
Research Associate, Konnerth Laboratory
Saarland University
Postdoctoral Fellow
Max Delbrueck Centrum for Molecular Medicine, Berlin
Postdoctoral Fellow
Max Planck Institute for Medical Research, Heidelberg


Byung Il Lee, Ph.D.

Research Fellow

Korea Advanced Institute for Science and Technology (KAIST)





Dr. Ulf Neumann
Novartis Institutes of BioMedical Research, Basel, Switzerland

BACE inhibitor CNP520 for prevention of Alzheimer’s disease

Wednesday 18 September 2019
3PM – 4.30PM
Cruciform Building, Gower Street, Boardroom

Dr. Hongbo Jia
Suzhou Institute of Biomedical Engineering and Technology,
Chinese Academy of Sciences

‘Holistic Bursting’: A logic of learning-transformed single-cell firing mode

Friday 13 September 2019
12PM – 13PM
Cruciform Building, Gower Street, Boardroom

Join us

We are looking for exceptional scientists to build a multidisciplinary team of researchers passionate about neuroscience! If you are looking for a position as a PhD student or Postdoc please send us an email. Candidates with experience in molecular and systems neuroscience, engineering, and computational biology are especially encouraged to apply.