Selected Peer-Reviewed Publications

View all published literature here.

Synergy between amyloid-β and tau in Alzheimer’s disease.
Busche MA & Hyman BT
Nature Neuroscience (2020)


Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer’s Disease.
Harris SS, Wolf F, De Strooper B, Busche MA
Neuron (2020)


Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
Pigoni M, Hsia H, Hartmann J, Njavro JR, Shmueli MD, Müller SA, Güner G, Tüshaus J, Kuhn P, Kumar R, Gao P, Tran ML, Ramazanov B, Blank B, Hipgrave Ederveen AL, Von Blume J, Mulle C, Gunnersen JM, Wuhrer M, Rammes G, Busche MA, Koeglsperger T, Lichtenthaler SF
EMBO Journal (2020)


Tau suppresses neuronal activity in vivo, even before tangles form.
Busche MA
Brain (2019)


Tau impairs neural circuits, dominating amyloid-ß effects, in Alzheimer models in vivo.
Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT
Nature Neuroscience (2019)


What happens with the circuit in Alzheimer’s disease in mice and humans?
Zott B, Busche MA, Sperling RA & Konnerth A
Annual Review of Neuroscience (2018)


BACE Inhibition-dependent repair of Alzheimer’s pathophysiology.
Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A & Busche MA
Proceedings of the National Academy of Sciences (2017)


Impairments of neural circuit function in Alzheimer’s disease.
Busche MA & Konnerth A
Philosophical Transactions of the Royal Society B (2016)


Decreased amyloid-beta and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models.
Busche MA, Grienberger C, Keskin AD, Song B, Neumann U, Staufenbiel M, Förstl H & Konnerth A
Nature Neuroscience (2015)


Rescue of long-range circuit dysfunction in Alzheimer’s disease models.
Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I & Konnerth A
Nature Neuroscience (2015)


η-secretase processing of APP inhibits neuronal activity in the hippocampus.
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H & Haass C
Nature (2015)


Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease.
Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B & Konnerth A.
Proceedings of the National Academy of Sciences (2012)


Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer’s disease.
Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A & Garaschuk O
Science (2008)
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