Marc Aurel Busche, M.D., Ph.D.
Principal Investigator, UK Dementia Research Institute, University College London
Honorary Consultant Psychiatrist, QueenSquare National Hospital for Neurology and Neurosurgery
Education
EMBO Long-Term Fellow, Massachusetts General Hospital & Harvard Medical School.
Clinical Residency in Psychiatry, University Hospital Klinikum Rechts der Isar, Munich.
Postdoctoral Researcher, Institute of Neuroscience, Munich.
M.D./Ph.D., Medical Life Sciences and Technology, Technical University of Munich.
Awards
UKRI Future Leaders Fellowship
AD/PD Junior Faculty Award
Kurt Kaufmann Prize
GSK Award for Clinical Research
EMPIRIS Award, Felgenhauer Award
Hans Jörg Weitbrecht Prize
Hans Heimann Prize
Previous Employment
Locum editor/editor, Biomed Central (Springer Nature), London.
Senior Postdoctoral Research Associate, Department of Psychology, University of Sheffield.
Postdoctoral Research Associate (secondment), Health Economics and Decision Science, School of Health and Related Research , University of Sheffield.
Joint postdoctoral position, Department of Psychology, University of Sheffield & Department of Neurological Surgery, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, USA.
Clinical Autonomic Scientist, National Hospital for Neurology and Neurosurgery, UCLH.
Education
Ph.D. Neuroscience, University of Sheffield.
MSc Medical Physics, University of Surrey.
BSc Physics with Astronomy, University of Southampton.
Awards
Co-investigator on Eisai / UK DRI Research Programme on Dementia grant entitled: ‘Longitudinal monitoring of neurovascular dynamics in models of neurodegeneration’.
Co-investigator on MRC – KHIDI UK-Korea Partnering Award entitled: ‘Integrating multimodal imaging technologies to investigate neurovascular dysfunction in neurological disorders’.
Co-investigator on Epilepsy Research UK project entitled: ‘How activation of sensory regions can promote propagation of adjacent focal neocortical seizures’.
Exceptional Contribution Award for sustained research excellence (University of Sheffield).
Exceptional Contribution Award for research excellence (University of Sheffield).
Engineering and Physical Sciences Research Council ‘Pathways to Impact’ bursary for Science Communication.
Gold CREST (CREativity in Science and Technology) Award from the British Science Association.
Current Work in Our Lab
In addition to being involved in all aspects of the day to day management of the laboratory and staff training, I am also engaged in research examining neurovascular circuit dynamics in translational models of neuro-degenerative diseases, through the development and application of cutting-edge multi-modal imaging and electrophysiological techniques.
Previous Position
Postdoctoral Resesearcher, Korea Advanced Institute of Science and Technology.
Education
BSc, Korea Advanced Institute of Science and Technology.
MS/Ph.D. integrated, Korea Advanced Institute of Science and Technology.
Awards
Next-generation Researcher Fostering Program 2019 – National Research Foundation or Korea.
Current Work in Our Lab
My works mainly focus on the in vivo monitoring of the neural excitability in the cortex of neurodegenerative model mouse brains by using two-photon microscopy. Accompanying in vitro studies to elucidate the mechanisms of the abnormalities are also in progress. Imaging the cleared brains with light-sheet microscopy to investigate structural and functional alteration as results of disease progression is another research interest.
Previous Position
Postdoctoral Training Fellow, The Francis Crick Institute, London.
Education
Ph.D. Neurophysiology, Indian Institute of Science, Bangalore.
BTech Biotechnology, National Institute of Technology, Durgapur, India.
Future Work in Our Lab
I will be doing in vivo patch clamp electrophysiology to work on neurodegenerative models in the cortex and hippocampus.
Previous Position
Research Associate, Konnerth Laboratory, Technical University of Munich.
Postdoctoral Fellow, Saarland University.
Postdoctoral Fellow, Max Delbrück Centrum for Molecular Medicine, Berlin.
Education
Ph.D., Max Planck Institute for Medical Research, Heidelberg.
Diploma in Biophysics, Humboldt-University Berlin.
Dr. rer. nat. Ruprecht-Karls-University Heidelberg.
Current Work in Our Lab
For many years I have been researching basic mechanisms of glutamatergic synaptic transmission in neurons of the central nervous system. I have also gained expertise in the use of patch clamp techniques and confocal calcium imaging in acute mouse brain slices. My aim is to use this knowledge to break down pathogenic processes at the level of single cells and synapses to unravel the effects of Aβ and tau in Alzheimer’s disease.
“TRPC3 channels are required for synaptic transmission and motor coordination”
Education
Ph.D. Optics, Key Laboratory of Optical System Advanced Manufacturing Technology, Changchun Institute of Optics, Fine Mechanics and Physics and Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences.
Current Work in Our Lab
By developing a multiarea two-photon imaging technique, we are trying to explore the interaction and connection between several significant brain areas under the influence of tau and Aβ, which is conducive to understanding and repairing neural circuits in Alzheimer’s disease.
“MATRIEX imaging: multiarea two-photon real-time in vivo explorer”
Previous Positions
Postdoctoral Researcher, INSERM Institute of Psychiatry and Neuroscience of Paris.
Joint Research Fellow, MRC Centre for Regenerative Medicine, University of Edinburgh and University of Strathclyde
Education
Ph.D. Regenerative Medicine, MRC Centre for Regenerative Medicine, University of Edinburgh.
MA Natural Sciences, University of Cambridge.
Awards
UK DRI Pilot Studies Programme Award 2020
Association CADASIL France Prize 2018
Current Work in Our Lab
My work looks at the contribution of non-neuronal cell types to Alzheimer’s Disease and dementia, with a focus on oligodendrocytes and the vasculature. This work involves studying these cells in vitro and in vivo to test hypotheses generated using single cell RNA sequencing of human tissue.
Education
Ph.D. Developmental Neuroscience, Centre for Developmental Neurobiology, King’s College London.
Marten Kehring
MD student
Robert Kilzer
MD student
Jana Zünkler
MD student
Mariam Hellmuth
MD Student
Francesca Kar Wey Lam
PhD Student
Busche Lab - UKDRI at UCL 